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KPV works to reduce inflammation and regulate immune overactivity inside the intestinal lining

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MAbs 7:311321 Neri P, Maity R, Tagoug I, McCulloch S, Duggan P, Jimenez-Zepeda V et al (2018) Immunome single cell profiling reveals T cell exhaustion with upregulation of checkpoint inhibitors LAG3 and Tigit on marrow infiltrating T lymphocytes in daratumumab and IMiDs resistant patients

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The Phase 2 trial demonstrated that higher doses produce greater reductions in body weight, with the 12mg group achieving 24.2% average weight loss at 48 weeks